反应详情

温度

27.5 °C

Clopidogrel base was dissolved in diethyl ether at 20-25° C. To this was added benzene sulphonic acid dissolved in diethyl ether. The reaction mixture was stirred at 25-30° C. for 24-30 hrs. The white solid was collected by filtration, washed with diethyl ether, and dried at 50-60° C. in a vacuum oven to obtain Clopidogrel besylate crystalline form.

1. filtrationThe white solid was collected by filtration
2. washwashed with diethyl ether
3. customdried at 50-60° C. in a vacuum oven