Methyl 6-(chloromethyl)nicotinate → 6-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxymethyl}-nicotinic acid methyl ester

HRID 1539196Notes

Reaction equation

HRID 1539196 reaction equation
[CH3:28][O:29][C:30]([c:31]1[cH:32][n:33][c:34]([CH2:37][Cl:38])[cH:35][cH:36]1)=[O:39].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][OH:15])[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][O:15][CH2:37][c:34]2[n:33][cH:32][c:31]([C:30]([O:29][CH3:28])=[O:39])[cH:36][cH:35]2)[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 15331516Methyl 6-(chloromethyl)nicotinateHCID 666193102-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol

Product 1

HCID 666194816-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxymethyl}-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-ddc95e25a6a34d22a25b73190fb48de0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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