Benzene → 3-Fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

HRID 1539264Notes

Reaction equation

HRID 1539264 reaction equation
[F:1][CH:2]([C:3](=[O:4])[N:5]([CH3:6])[c:7]1[c:8]([C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)=[N:16][OH:23])[cH:18][c:19]([Cl:22])[cH:20][cH:21]1)[I:17].[S:30]([Cl:31])([Cl:32])=[O:33].[cH:24]1[cH:25][cH:26][n:27][cH:28][cH:29]1.[cH:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[F:1][CH:2]1[C:3](=[O:4])[N:5]([CH3:6])[c:7]2[c:8]([cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)=[N:16]1

Participants

5

Reactant 4

HCID 241BenzeneHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 86737319HCID 86737319, compound

Product 1

HCID 126021203-Fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

Sources & evidence

ORD record
ord-b8801ac224504e99aa6fbbaf60d6e1e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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