Acetic Acid → N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-8-bromo-2-cyclopropyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-4-amine

HRID 1539973Notes

Reaction equation

HRID 1539973 reaction equation
[C:40]([O:41][BH-:42]([O:43][C:44](=[O:45])[CH3:46])[O:47][C:48](=[O:49])[CH3:50])(=[O:51])[CH3:52].[CH3:20][C:21](=[O:22])[OH:23].[Cl:54][CH2:55][Cl:56].[F:24][C:25]([c:26]1[cH:27][c:28]([CH:29]=[O:30])[cH:31][c:32]([C:34]([F:35])([F:36])[F:37])[cH:33]1)([F:38])[F:39].[NH2:1][CH:2]1[CH2:3][CH:4]([CH:17]2[CH2:18][CH2:19]2)[NH:5][c:6]2[c:7]([Br:16])[cH:8][c:9]([C:12]([F:13])([F:14])[F:15])[cH:10][c:11]21.[Na+:53]>>[NH:1]([CH:2]1[CH2:3][CH:4]([CH:17]2[CH2:18][CH2:19]2)[NH:5][c:6]2[c:7]([Br:16])[cH:8][c:9]([C:12]([F:13])([F:14])[F:15])[cH:10][c:11]21)[CH2:29][c:28]1[cH:27][c:26]([C:25]([F:24])([F:38])[F:39])[cH:33][c:32]([C:34]([F:35])([F:36])[F:37])[cH:31]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 923Sodium ionHCID 6344DichloromethaneHCID 1362473,5-Bis(trifluoromethyl)benzaldehydeHCID 2724942TriacetoxyborohydrideHCID 223942438-Bromo-2-cyclopropyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-4-amine

Product 1

HCID 22394229N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-8-bromo-2-cyclopropyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-4-amine

Sources & evidence

ORD record
ord-b8ffbb049187413c9ad2b6bd38cbf743
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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