tert-Butyl 5-(6-Bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)isoindoline-2-carboxylate → 5-Bromo-3-(isoindolin-5-ylamino)-1-methylpyrazin-2(1H)-one

HRID 1540691Notes

Reaction equation

HRID 1540691 reaction equation
[Br:46][c:47]1[cH:48][n:49]([CH3:71])[c:50](=[O:70])[c:51]([NH:53][c:54]2[cH:55][c:56]3[c:60]([cH:61][cH:62]2)[CH2:59][N:58]([C:63]([O:64][C:65]([CH3:66])([CH3:67])[CH3:68])=[O:69])[CH2:57]3)[n:52]1.[C:1]([O:2][CH2:3][c:4]1[c:5]([N:6]2[CH2:7][CH2:8][n:9]3[c:10]4[c:15]([cH:16][c:17]3[C:18]2=[O:19])[CH2:14][CH2:13][CH2:12][CH2:11]4)[cH:20][c:21]([F:22])[cH:23][c:24]1-[c:25]1[n:26][c:27]([NH:28][c:29]2[cH:30][c:31]3[c:32]([cH:33][cH:34]2)[CH2:35][NH:36][CH2:37][CH2:38]3)[c:39](=[O:40])[n:41]([CH3:42])[cH:43]1)(=[O:44])[CH3:45]>>[Br:46][c:47]1[cH:48][n:49]([CH3:71])[c:50](=[O:70])[c:51]([NH:53][c:54]2[cH:55][c:56]3[c:60]([cH:61][cH:62]2)[CH2:59][NH:58][CH2:57]3)[n:52]1

Participants

3

Reactant 2

HCID 58044192tert-Butyl 5-(6-Bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)isoindoline-2-carboxylateHCID 670162104-Fluoro-2-(4-methyl-5-oxo-6-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)-4,5-dihydropyrazin-2-yl)-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl Acetate

Product 1

HCID 580437075-Bromo-3-(isoindolin-5-ylamino)-1-methylpyrazin-2(1H)-one

Sources & evidence

ORD record
ord-e67a15ccae0b4e9ea7c615a0818f5d67
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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