HCID 10037837, compound → HCID 17975631, compound

HRID 15414Notes

Reaction equation

HRID 15414 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)[N:5]2[CH:17]=[N:18][CH:19]=[C:4]2[CH2:3]1.O(CC)CC.[ClH:25]>CC(C)=O>[ClH:25].[CH3:1][N:2]1[C:7](=[O:8])[CH:6]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)[N:5]2[CH:17]=[N:18][CH:19]=[C:4]2[CH2:3]1

Participants

4

Reactant 2

HCID 10037837HCID 10037837, compoundHCID 10953452Ether hydrochloride

Product 1

HCID 17975631HCID 17975631, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound is prepared analogously to Example 1, i.e., 4-(7-methyl-6-oxo-5,6,7,8-tetrahydro-imidazol[1,5-a]pyrazin-5-yl)-benzonitrile, obtained analogously to Example 1, is dissolved in acetone, then treated with Et2O—HCl(g) to afford the hydrochloride salt: m.p. 222-224° C.; 1H-NMR (DMSO-d6) 9.07 (1H, s), 7.92 (2H, d, J=8.2), 7.48 (1H, s), 7.49 (2H, d, J=8.2), 6.46 (1H, s), 4.83 (2H, s), 3.03 (3H, s); 13C-NMR (DMSO-d6) δ 162.5, 140.5, 134.3, 133.4, 128.7, 125.1, 118.6, 115.7, 112.4, 60.9, 43.1, 34.9; e/z (ES) 253 (M+1, 100%); calculated for C14H12N4O HCl 0.4H2O, C, 56.82; H, 4.70; N, 18.93. found C, 56.88; H, 4.54; N, 18.89.

Workup

  1. customobtained analogously to Example 1

Sources & evidence

ORD record
ord-1e75a606a2214c71a014e3c60fa45eeb
Source dataset
uspto-grants-2010_06
Patent number
US07732603B2

Reaction notes

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