6-chloro-N-(3-methoxybenzyl)nicotinamide → 6-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(3-methoxybenzyl)nicotinamide

HRID 1541918Notes

Reaction equation

HRID 1541918 reaction equation
[CH:20]1([NH:23][C:24]([c:25]2[cH:26][c:27]([B:32]3[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]3)[c:28]([CH3:31])[cH:29][cH:30]2)=[O:41])[CH2:21][CH2:22]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][CH2:9][c:10]2[cH:11][c:12]([O:16][CH3:17])[cH:13][cH:14][cH:15]2)[cH:18][cH:19]1>>[c:2]1(-[c:27]2[cH:26][c:25]([C:24]([NH:23][CH:20]3[CH2:21][CH2:22]3)=[O:41])[cH:30][cH:29][c:28]2[CH3:31])[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][CH2:9][c:10]2[cH:11][c:12]([O:16][CH3:17])[cH:13][cH:14][cH:15]2)[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 94957946-chloro-N-(3-methoxybenzyl)nicotinamideHCID 21914577N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Product 1

HCID 219145686-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(3-methoxybenzyl)nicotinamide

Sources & evidence

ORD record
ord-ab325d0d40ca480d8eaff32ff3c7bb15
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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