tert-Butyl piperazine-1-carboxylate → 4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15](=[O:16])[n:17]([CH2:18][CH:19]([CH3:20])[CH3:21])[n:22][c:23](-[c:24]3[cH:25][cH:26][c:27]([CH3:28])[c:29]([F:30])[cH:31]3)[c:32]2[CH3:33])[CH2:12][CH2:13]1.[F:34][c:35]1[cH:36][c:37](-[c:43]2[cH:44][c:45]([CH2:60][O:61][S:62]([CH3:63])(=[O:64])=[O:65])[c:46](=[O:59])[n:47]([CH2:49][CH2:50][CH2:51][c:52]3[cH:53][cH:54][c:55]([F:58])[cH:56][cH:57]3)[n:48]2)[cH:38][cH:39][c:40]1[O:41][CH3:42].[N:66]1([C:67]([O:68][C:69]([CH3:70])([CH3:71])[CH3:72])=[O:73])[CH2:74][CH2:75][NH:76][CH2:77][CH2:78]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:60][c:45]2[cH:44][c:43](-[c:37]3[cH:36][c:35]([F:34])[c:40]([O:41][CH3:42])[cH:39][cH:38]3)[n:48][n:47]([CH2:49][CH2:50][CH2:51][c:52]3[cH:53][cH:54][c:55]([F:58])[cH:56][cH:57]3)[c:46]2=[O:59])[CH2:12][CH2:13]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-1890c59664714ceba7d4b3e6728fac48
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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