Sulfamic acid 2,2,2-trifluoro-1,1-dimethyl-ethyl ester → 2-[2-Ethyl-1-(2,2,2-trifluoro-1,1-dimethyl-ethoxysulfonylaminocarbonyl)-cyclopropylcarbamoyl]-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:26]([NH:27][C:28]2([C:33](=[O:34])[OH:35])[CH:29]([CH2:31][CH3:32])[CH2:30]2)=[O:36])[CH2:10][CH:11]([O:13][c:14]2[n:15][cH:16][cH:17][c:18]3[cH:19][c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1.[F:37][C:38]([C:39]([CH3:40])([CH3:41])[O:42][S:43]([NH2:44])(=[O:45])=[O:46])([F:47])[F:48]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:26]([NH:27][C:28]2([C:33](=[O:35])[NH:44][S:43]([O:42][C:39]([C:38]([F:37])([F:47])[F:48])([CH3:40])[CH3:41])(=[O:45])=[O:46])[CH:29]([CH2:31][CH3:32])[CH2:30]2)=[O:36])[CH2:10][CH:11]([O:13][c:14]2[n:15][cH:16][cH:17][c:18]3[cH:19][c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-588b8f62796a4ff584885f27096aa915
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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