Hydroxide → 3-methyl-4-(3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)cyclopentanamine

HRID 1542251Notes

Reaction equation

HRID 1542251 reaction equation
[CH2:1]([N:8]([CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:35]1)[CH:9]1[CH2:10][CH:11]([CH3:34])[CH:12]([c:14]2[cH:15][n:16][c:17]3[n:18]2[c:19]2[c:20]([n:21][cH:22]3)[n:23]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:24][cH:25]2)[CH2:13]1)[c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[F:44][CH2:45][C:46]([F:47])([F:48])[OH:49].[H:42][H:43].[OH-:50].[OH-:52].[Pd+2:51]>>[NH2:8][CH:9]1[CH2:10][CH:11]([CH3:34])[CH:12]([c:14]2[cH:15][n:16][c:17]3[n:18]2[c:19]2[c:20]([n:21][cH:22]3)[n:23]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:24][cH:25]2)[CH2:13]1

Participants

6

Reactant 5

HCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 185647Ethanol, trifluoro-HCID 58557169N,N-dibenzyl-3-methyl-4-(3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)cyclopentanamineHCID 178418361HCID 178418361, compound

Product 1

HCID 585575733-methyl-4-(3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)cyclopentanamine

Sources & evidence

ORD record
ord-0c269f35c10b43eda9135a52ec5b6495
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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