1-(6-Chloropyridin-3-yl)-2,2,2-trifluoroethan-1-ol → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 1542603Notes

Reaction equation

HRID 1542603 reaction equation
[Cl:21][c:22]1[cH:23][cH:24][c:25]([CH:28]([C:29]([F:30])([F:31])[F:32])[OH:33])[cH:26][n:27]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:22]1[cH:23][cH:24][c:25]([CH:28]([C:29]([F:30])([F:31])[F:32])[OH:33])[cH:26][n:27]1

Participants

3

Reactant 2

HCID 199715811-(6-Chloropyridin-3-yl)-2,2,2-trifluoroethan-1-olHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595261595-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-db6929e4fab34a26a238bbdf9de43055
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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