5-Boronothiophene-2-carboxylic acid → 5-[5-Amino-6-[(2-chloro-3,6-difluorophenyl)methoxy]pyrazin-2-yl]thiophene-2-carboxylic acid
Reaction equation
[Br:1][c:2]1[n:3][c:4]([O:9][CH2:10][c:11]2[c:12]([Cl:19])[c:13]([F:18])[cH:14][cH:15][c:16]2[F:17])[c:5]([NH2:8])[n:6][cH:7]1.[C:20](=[O:21])([OH:22])[c:23]1[cH:24][cH:25][c:26]([B:28]([OH:29])[OH:30])[s:27]1>>[c:2]1(-[c:26]2[cH:25][cH:24][c:23]([C:20](=[O:21])[OH:22])[s:27]2)[n:3][c:4]([O:9][CH2:10][c:11]2[c:12]([Cl:19])[c:13]([F:18])[cH:14][cH:15][c:16]2[F:17])[c:5]([NH2:8])[n:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-e42ece6a577c4a84b93c3b71f2040fd7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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