N-(4-bromo-2-fluorophenyl)acetamide → N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

HRID 1543433Notes

Reaction equation

HRID 1543433 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:12])[c:5]([NH:6][C:7]([CH3:8])=[O:9])[cH:10][cH:11]1.[CH3:13][C:14]1([CH3:28])[O:15][C:16](=[O:27])[NH:17][c:18]2[c:19]1[cH:20][c:21]([B:24]([OH:25])[OH:26])[cH:22][cH:23]2>>[c:2]1(-[c:21]2[cH:20][c:19]3[c:18]([cH:23][cH:22]2)[NH:17][C:16](=[O:27])[O:15][C:14]3([CH3:13])[CH3:28])[cH:3][c:4]([F:12])[c:5]([NH:6][C:7]([CH3:8])=[O:9])[cH:10][cH:11]1

Participants

3

Reactant 2

HCID 67593N-(4-bromo-2-fluorophenyl)acetamideHCID 10987806(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

Product 1

HCID 23509628N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

Sources & evidence

ORD record
ord-f31a7fc81fad4087b12c46c41a961c5b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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