2-Chloro-5-(trifluoromethyl)benzonitrile → Tert-butyl 4-[2-cyano-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

HRID 1543701Notes

Reaction equation

HRID 1543701 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[Cl:14][c:15]1[c:16]([C:17]#[N:18])[cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][N:11]([c:15]2[c:16]([C:17]#[N:18])[cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 676042-Chloro-5-(trifluoromethyl)benzonitrileHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 59793685Tert-butyl 4-[2-cyano-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-2044eba2bdd44b1784754a11abc05dce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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