Acetonitrile → N'-(5-bromo-4-(4-chlorophenyl)pyridin-2-yl)-2-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)acetohydrazide

HRID 1543944Notes

Reaction equation

HRID 1543944 reaction equation
[Br:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]2)[cH:4][c:5]([NH:8][NH2:9])[n:6][cH:7]1.[Br:39][P+:40]([N:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1)([N:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1)[N:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1.[Br:56][c:57]1[c:58](-[c:59]2[cH:60][cH:61][c:62]([Cl:63])[cH:64][cH:65]2)[cH:66][c:67]([NH:68][NH:69][C:70](=[O:71])[CH2:72][c:73]2[cH:74][n:75][c:76]([C:77]([F:78])([F:79])[F:80])[cH:81][cH:82]2)[n:83][cH:84]1.[CH3:17][c:18]1[n:19][c:20]([C:28]([F:29])([F:30])[F:31])[cH:21][cH:22][c:23]1[CH2:24][C:25](=[O:26])[OH:27].[CH3:85][C:86]#[N:87].[P-:32]([F:33])([F:34])([F:35])([F:36])([F:37])[F:38]>>[Br:1][c:2]1[c:3](-[c:10]2[cH:11][cH:12][c:13]([Cl:16])[cH:14][cH:15]2)[cH:4][c:5]([NH:8][NH:9][C:25]([CH2:24][c:23]2[c:18]([CH3:17])[n:19][c:20]([C:28]([F:29])([F:30])[F:31])[cH:21][cH:22]2)=[O:26])[n:6][cH:7]1

Participants

7

Reactant 6

HCID 6342AcetonitrileHCID 9886HexafluorophosphateHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 115575962-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)acetic acidHCID 57979738N'-(5-bromo-4-(4-chlorophenyl)pyridin-2-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetohydrazideHCID 579797505-Bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine

Product 1

HCID 57979751N'-(5-bromo-4-(4-chlorophenyl)pyridin-2-yl)-2-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)acetohydrazide

Sources & evidence

ORD record
ord-4486f9ad106048d4aad44706c4310e60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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