Ethyl 5-amino-1H-indole-2-carboxylate → N2-(2-ethoxycarbonylindol-5-yl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 1544227Notes

Reaction equation

HRID 1544227 reaction equation
[CH2:20]([CH3:21])[O:22][C:23](=[O:24])[c:25]1[nH:26][c:27]2[cH:28][cH:29][c:30]([NH2:34])[cH:31][c:32]2[cH:33]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1>>[c:2]1([NH:34][c:30]2[cH:29][cH:28][c:27]3[nH:26][c:25]([C:23]([O:22][CH2:20][CH3:21])=[O:24])[cH:33][c:32]3[cH:31]2)[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1

Participants

3

Reactant 2

HCID 10726872Ethyl 5-amino-1H-indole-2-carboxylateHCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine

Product 1

HCID 22060281N2-(2-ethoxycarbonylindol-5-yl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-7e755eeb1d99456488edf6be2cd7e16e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…