2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1-hydroxy-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 1544347Notes

Reaction equation

HRID 1544347 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:8]([CH3:9])([OH:10])[c:11]2[n:12][n:13][n:14]([CH2:16][CH2:17][OH:18])[cH:15]2)[n:7]1.[NH2:19][c:20]1[s:21][c:22](-[c:28]2[c:29]([F:38])[cH:30][c:31]([C:34]([CH3:35])([CH3:36])[OH:37])[cH:32][cH:33]2)[cH:23][c:24]1[C:25](=[O:26])[NH2:27]>>[c:2]1([NH:19][c:20]2[s:21][c:22](-[c:28]3[c:29]([F:38])[cH:30][c:31]([C:34]([CH3:35])([CH3:36])[OH:37])[cH:32][cH:33]3)[cH:23][c:24]2[C:25](=[O:26])[NH2:27])[cH:3][cH:4][cH:5][c:6]([C:8]([CH3:9])([OH:10])[c:11]2[n:12][n:13][n:14]([CH2:16][CH2:17][OH:18])[cH:15]2)[n:7]1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595261461-(6-Bromopyridin-2-yl)-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethanol

Product 1

HCID 595257915-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1-hydroxy-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-a3eed95400ba45c9b56cfdc39e44910a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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