4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine → 4-chloro-5-(5-(4-ethylpiperazin-1-yl)pent-1-ynyl)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

HRID 1544438Notes

Reaction equation

HRID 1544438 reaction equation
[CH2:24]([CH3:25])[N:26]1[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][CH2:34][C:35]#[CH:36])[CH2:30][CH2:31]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[I:12]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[C:36]#[C:35][CH2:34][CH2:33][CH2:32][N:29]1[CH2:28][CH2:27][N:26]([CH2:24][CH3:25])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 442289644-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amineHCID 866082201-Ethyl-4-(pent-4-ynyl)piperazine

Product 1

HCID 577138334-chloro-5-(5-(4-ethylpiperazin-1-yl)pent-1-ynyl)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Sources & evidence

ORD record
ord-42607e44df744f469692846301ba29db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…