(3-Chloro-4-(dimethylcarbamoyl)phenyl)boronic acid → 2-chloro-4-[5-[1-(3-fluorophenyl)-2-methyl-3-oxo-3-(1,3,4-thiadiazol-2-ylamino)propyl]thiophen-2-yl]-N,N-dimethylbenzamide

HRID 1544543Notes

Reaction equation

HRID 1544543 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:7]([CH:8]([C:9](=[O:10])[NH:11][c:12]2[s:13][cH:14][n:15][n:16]2)[CH3:17])[c:18]2[cH:19][c:20]([F:24])[cH:21][cH:22][cH:23]2)[s:6]1.[Cl:25][c:26]1[cH:27][c:28]([B:37]([OH:38])[OH:39])[cH:29][cH:30][c:31]1[C:32]([N:33]([CH3:34])[CH3:35])=[O:36]>>[c:2]1(-[c:28]2[cH:27][c:26]([Cl:25])[c:31]([C:32]([N:33]([CH3:34])[CH3:35])=[O:36])[cH:30][cH:29]2)[cH:3][cH:4][c:5]([CH:7]([CH:8]([C:9](=[O:10])[NH:11][c:12]2[s:13][cH:14][n:15][n:16]2)[CH3:17])[c:18]2[cH:19][c:20]([F:24])[cH:21][cH:22][cH:23]2)[s:6]1

Participants

3

Reactant 2

HCID 44119415(3-Chloro-4-(dimethylcarbamoyl)phenyl)boronic acidHCID 591385913-(5-bromothiophen-2-yl)-3-(3-fluorophenyl)-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide

Product 1

HCID 591385942-chloro-4-[5-[1-(3-fluorophenyl)-2-methyl-3-oxo-3-(1,3,4-thiadiazol-2-ylamino)propyl]thiophen-2-yl]-N,N-dimethylbenzamide

Sources & evidence

ORD record
ord-6575d2bb16474a4f886ccf890adb183f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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