5-(2,2-Difluoro-ethoxy)-pyridine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4,6,6-trimethyl-1,3-oxazin-4-yl)-4-fluorophenyl]-5-(2,2-difluoroethoxy)pyridine-2-carboxamide
Reaction equation
[F:21][CH:22]([CH2:23][O:24][c:25]1[cH:26][cH:27][c:28]([C:31](=[O:32])[OH:33])[n:29][cH:30]1)[F:34].[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]2([CH3:19])[N:9]=[C:10]([NH2:18])[O:11][C:12]([CH3:16])([CH3:17])[C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]2([CH3:19])[N:9]=[C:10]([NH2:18])[O:11][C:12]([CH3:16])([CH3:17])[C:13]2([F:14])[F:15])[cH:7]1)[C:31]([c:28]1[cH:27][cH:26][c:25]([O:24][CH2:23][CH:22]([F:21])[F:34])[cH:30][n:29]1)=[O:32]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-dc751d0d7d214a65874f3557e6c95bee
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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