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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1544617Generated: October 26, 2026

Dimethylformamide → tert-butyl 5-amino-4-[7-[(3,4-difluorophenyl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

https://huagongshe.com/reaction/1544617

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantCarbonate IonHCID 19660—
ReactantDiisopropylethylamineHCID 81531—
ReactantCesium cationHCID 104967—
Reactant3,4-Difluorobenzyl ChlorideHCID 2736954—
Reactant4-Carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl esterHCID 67336544—
Producttert-butyl 5-amino-4-[7-[(3,4-difluorophenyl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoateHCID 67335690—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (1/10)
ORD IDord-7b7465c7c4ca46e5962dbbf6b849b92e
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (1/10)