Methanol → N-(1-tert-butoxycarbonyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-4-piperidinecarboxamide

HRID 1545877Notes

Reaction equation

HRID 1545877 reaction equation
[C+4:39].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][CH:14]([C:17](=[O:18])[NH:19][c:20]2[c:21]3[c:22]([n:23][cH:24][cH:25]2)[n:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:27][cH:28]3)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:36][OH:37].[OH-:38].[OH-:41].[OH-:42].[OH-:43].[OH-:44].[OH-:45].[Pd+2:40]>>[NH:11]1[CH2:12][CH2:13][CH:14]([C:17](=[O:18])[NH:19][c:20]2[c:21]3[c:22]([n:23][cH:24][cH:25]2)[n:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:27][cH:28]3)[CH2:15][CH2:16]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide6×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 22393147N-(1-tert-Butoxycarbonyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-benzyloxycarbonyl-4-piperidinecarboxamideHCID 178420935HCID 178420935, compound

Product 1

HCID 22393167N-(1-tert-butoxycarbonyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-4-piperidinecarboxamide

Sources & evidence

ORD record
ord-dbad3a528e2c4b58b94e435c03ae5c2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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