1-Tert-butyl 2-methyl pyrrolidine-1,2-dicarboxylate → Tert-butyl 2-[2,8-bis(trifluoromethyl)quinoline-4-carbonyl]pyrrolidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:16]([F:17])([F:18])[F:19])[n:5][c:6]2[c:7]([C:12]([F:13])([F:14])[F:15])[cH:8][cH:9][cH:10][c:11]12.[CH3:20][O:21][C:22]([CH:23]1[N:24]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:25][CH2:26][CH2:27]1)=[O:35]>>[c:2]1([C:22](=[O:21])[CH:23]2[N:24]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:25][CH2:26][CH2:27]2)[cH:3][c:4]([C:16]([F:17])([F:18])[F:19])[n:5][c:6]2[c:7]([C:12]([F:13])([F:14])[F:15])[cH:8][cH:9][cH:10][c:11]12Participants
3
Sources & evidence
- ORD record
- ord-6d77c3e2e78b4e3ea11eef71701d5094
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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