2-(Chloromethyl)-1,3-oxazole → 2-[[6-[[6-(Azetidin-1-yl)-3-pyridinyl]sulfonyl]-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]methoxymethyl]-1,3-oxazole

HRID 1546152Notes

Reaction equation

HRID 1546152 reaction equation
[Cl:36][CH2:37][c:38]1[o:39][cH:40][cH:41][n:42]1.[N:1]1([c:5]2[cH:6][cH:7][c:8]([S:11](=[O:12])(=[O:13])[N:14]3[CH2:15][C:16]4([CH2:34][OH:35])[CH2:17][c:18]5[c:19]([n:24](-[c:27]6[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]6)[n:25][cH:26]5)[CH:20]=[C:21]4[CH2:22][CH2:23]3)[cH:9][n:10]2)[CH2:2][CH2:3][CH2:4]1>>[N:1]1([c:5]2[cH:6][cH:7][c:8]([S:11](=[O:12])(=[O:13])[N:14]3[CH2:15][C:16]4([CH2:34][O:35][CH2:37][c:38]5[o:39][cH:40][cH:41][n:42]5)[CH2:17][c:18]5[c:19]([n:24](-[c:27]6[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]6)[n:25][cH:26]5)[CH:20]=[C:21]4[CH2:22][CH2:23]3)[cH:9][n:10]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 219575432-(Chloromethyl)-1,3-oxazoleHCID 68194437[6-[[6-(Azetidin-1-yl)-3-pyridinyl]sulfonyl]-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]methanol

Product 1

HCID 667804712-[[6-[[6-(Azetidin-1-yl)-3-pyridinyl]sulfonyl]-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]methoxymethyl]-1,3-oxazole

Sources & evidence

ORD record
ord-a1f69a706ba44ce589bc58bdb9ca92f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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