Acetate → tert-butyl (1'-benzyl-1-(5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

HRID 1546318Notes

Reaction equation

HRID 1546318 reaction equation
[C:31](=[O:32])([O-:33])[O-:34].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][NH:13][c:14]3[cH:15][cH:16][cH:17][c:18]([CH2:20][NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[c:19]32)[CH2:29][CH2:30]1.[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[Cl:44][c:45]1[c:46]2[c:47]([n:48][cH:49][n:50]1)[CH2:51][CH2:52][CH:53]2[CH2:54][CH3:55].[Cs+:35].[Cs+:36].[O-:57][C:58]([CH3:59])=[O:60].[O-:61][C:62]([CH3:63])=[O:64].[Pd+2:56]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][N:13]([c:45]3[c:46]4[c:47]([n:48][cH:49][n:50]3)[CH2:51][CH2:52][CH:53]4[CH2:54][CH3:55])[c:14]3[cH:15][cH:16][cH:17][c:18]([CH2:20][NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[c:19]32)[CH2:29][CH2:30]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 86651806Tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamateHCID 866518114-chloro-5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Product 1

HCID 86651812tert-butyl (1'-benzyl-1-(5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

Sources & evidence

ORD record
ord-5782c746feaf4c97b27efb321fdd7bea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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