Methanol → 8-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one

HRID 1546778Notes

Reaction equation

HRID 1546778 reaction equation
[CH3:1][O:2][C:3]([CH2:4][CH2:5][c:6]1[c:7]([NH:22][c:23]2[c:24]([F:30])[cH:25][cH:26][cH:27][c:28]2[F:29])[n:8][c:9]([S:20][CH3:21])[n:10][c:11]1-[c:12]1[c:13]([CH3:19])[cH:14][c:15]([F:18])[cH:16][cH:17]1)=[O:31].[CH3:32][O-:33].[CH3:35][OH:36].[Na+:34]>>[C:3]1(=[O:31])[CH2:4][CH2:5][c:6]2[c:7]([n:8][c:9]([S:20][CH3:21])[n:10][c:11]2-[c:12]2[c:13]([CH3:19])[cH:14][c:15]([F:18])[cH:16][cH:17]2)[N:22]1[c:23]1[c:24]([F:30])[cH:25][cH:26][cH:27][c:28]1[F:29]

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 3826051MethoxideHCID 66893833HCID 66893833, compound

Product 1

HCID 596396668-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one

Sources & evidence

ORD record
ord-a42c457c01c441b6adacc09da66ed626
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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