2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one-6-yl]-4-pyrimidineamine

HRID 1547983Notes

Reaction equation

HRID 1547983 reaction equation
[Cl:1][c:2]1[n:3][c:4]([NH:5][c:6]2[cH:7][cH:8][c:9]3[c:14]([cH:15]2)[O:13][CH2:12][CH2:11][O:10]3)[c:16]([F:17])[cH:18][n:19]1.[Cl:20][c:21]1[n:22][cH:23][c:24]([F:28])[c:25]([Cl:27])[n:26]1.[NH2:29][c:30]1[cH:31][cH:32][c:33]2[c:38]([n:39]1)[NH:37][C:36](=[O:40])[CH2:35][O:34]2>>[Cl:20][c:21]1[n:22][cH:23][c:24]([F:28])[c:25]([NH:29][c:30]2[cH:31][cH:32][c:33]3[c:38]([n:39]2)[NH:37][C:36](=[O:40])[CH2:35][O:34]3)[n:26]1

Participants

4

Reactant 3

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamineHCID 220605636-amino-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one

Product 1

HCID 220604032-chloro-5-fluoro-N4-[2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one-6-yl]-4-pyrimidineamine

Sources & evidence

ORD record
ord-1431d7309ce341d3bedd6d314d94bb39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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