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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1547989Generated: November 4, 2026

Bicarbonate Ion → 4-(4-methylpiperazin-1-yl)-6-[3-methyl-7-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

https://huagongshe.com/reaction/1547989

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBicarbonate IonHCID 769—
ReactantMethanolHCID 887—
ReactantSodium ionHCID 923—
ReactantWaterHCID 962—
Reactant1,4-DioxaneHCID 31275—
Reactant1-(Tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 45788496—
Reactant4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 59402317—
ReactantHCID 178420554HCID 178420554—
Product4-(4-methylpiperazin-1-yl)-6-[3-methyl-7-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amineHCID 46701981—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (1/10)
ORD IDord-edb1c84de95d49cf8899c196e42cdd1d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (1/10)