Ethanol → 4-N-Boc-2-hydroxymethylpiperazine

HRID 1548195Notes

Reaction equation

[C:3]([O:4][C:5](=[O:6])[N:10]1[CH:11]([CH2:23][OH:24])[CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]1)([CH3:7])([CH3:8])[CH3:9].[CH3:25][CH2:26][OH:27].[Na+:2].[OH-:1]>>[NH:10]1[CH:11]([CH2:23][OH:24])[CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]1

Participants

Reactant 4

HCID 702Ethanol

HCID 923Sodium ion

HCID 961Hydroxide

HCID 22711445Di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Product 1

HCID 223865084-N-Boc-2-hydroxymethylpiperazine

Sources & evidence

ORD record: ord-a8b5ad37cf2a4802a9005f45737274f6
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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