Pyridine → 3-Fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

HRID 1549110Notes

Reaction equation

HRID 1549110 reaction equation
[CH3:1][N:2]([C:3]([CH2:4][F:5])=[O:6])[c:7]1[c:8]([C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)=[N:16][OH:17])[cH:18][c:19]([Cl:22])[cH:20][cH:21]1.[CH3:23][NH:24][c:25]1[cH:26][cH:27][c:28]([Cl:29])[cH:30][c:31]1[C:32](=[N:33][OH:34])[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[F:41][CH2:42][C:43]([Cl:44])=[O:45].[cH:46]1[cH:47][cH:48][n:49][cH:50][cH:51]1>>[CH3:1][N:2]1[C:3](=[O:6])[CH:4]([F:5])[N:16]=[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[c:8]2[c:7]1[cH:21][cH:20][c:19]([Cl:22])[cH:18]2

Participants

5

Reactant 4

HCID 1049PyridineHCID 9663Fluoroacetyl chlorideHCID 54383801HCID 54383801, compoundHCID 74042289HCID 74042289, compound

Product 1

HCID 126021203-Fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

Sources & evidence

ORD record
ord-dde15bc56b2c49ea9e4483ea3f80a1cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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