4-(Bromomethyl)thiophene-2-carbonitrile → 4-[[3-Fluoro-4-[2-[(2-methylpyrrolidin-1-yl)methyl]pyrrolidine-1-carbonyl]phenoxy]methyl]thiophene-2-carbonitrile
Reaction equation
[Br:23][CH2:24][c:25]1[cH:26][c:27]([C:30]#[N:31])[s:28][cH:29]1.[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH:12]([CH2:16][N:17]3[CH:18]([CH3:22])[CH2:19][CH2:20][CH2:21]3)[CH2:13][CH2:14][CH2:15]2)[cH:4][cH:5][c:6]([OH:8])[cH:7]1>>[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[CH:12]([CH2:16][N:17]3[CH:18]([CH3:22])[CH2:19][CH2:20][CH2:21]3)[CH2:13][CH2:14][CH2:15]2)[cH:4][cH:5][c:6]([O:8][CH2:24][c:25]2[cH:26][c:27]([C:30]#[N:31])[s:28][cH:29]2)[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-6e353444cbf84ba6b4bf206496961d55
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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