Acetate → Tert-butyl 4-[1-(2-fluorophenyl)-imidazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate

HRID 1549699Notes

Reaction equation

HRID 1549699 reaction equation
[C:39]([O-:40])(=[O:41])[CH3:42].[C:44]([O-:45])(=[O:46])[CH3:47].[Cl:36][CH2:37][Cl:38].[Cu+2:43].[F:25][c:26]1[c:27]([O:32][B:33]([OH:34])[OH:35])[cH:28][cH:29][cH:30][cH:31]1.[cH:1]1[cH:2][cH:3][n:4][cH:5][cH:6]1.[nH:7]1[cH:8][n:9][c:10]([C:12]2=[CH:17][CH2:16][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:14][CH2:13]2)[cH:11]1>>[n:7]1(-[c:27]2[c:26]([F:25])[cH:31][cH:30][cH:29][cH:28]2)[cH:8][n:9][c:10]([C:12]2=[CH:17][CH2:16][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:14][CH2:13]2)[cH:11]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 1049PyridineHCID 6344DichloromethaneHCID 27099Cupric cationHCID 222378312-Fluorophenylboric acidHCID 178451779tert-butyl 4-(1H-imidazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

Product 1

HCID 58945849Tert-butyl 4-[1-(2-fluorophenyl)-imidazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate

Sources & evidence

ORD record
ord-4afa31c098a94ab9a6ac8682de0d4e65
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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