反应详情

A solution of 55 (1.24 g, 4.53 mmol) in ethanol (25 mL) was treated with sodium borohydride (102 mg, 2.72 mmol) at 25° C. After 1 h, the reaction mixture was concentrated in vacuo, diluted with ethyl acetate (40 mL), carefully treated with 5% aqueous hydrochloric acid (1×25 mL), the layers separated, and dried (MgSO4). The resulting solution was concentrated in vacuo to afford 56 (902.1 mg, 72%) as a colorless residue that was used without further purification. MS 298 (M+Na).

1. concentrationthe reaction mixture was concentrated in vacuo
2. additiondiluted with ethyl acetate (40 mL)
3. additioncarefully treated with 5% aqueous hydrochloric acid (1×25 mL)
4. customthe layers separated
5. dry with materialdried (MgSO4)
6. concentrationThe resulting solution was concentrated in vacuo