Dichloromethane → (4,4-Difluoro-piperidin-1-yl)-[5-(piperidin-4-yloxy)-1H-indol-2-yl]-methanone

HRID 1550351노트

반응식

HRID 1550351 반응식
[C:8]([O:9][C:10](=[O:11])[N:15]1[CH2:16][CH2:17][CH:18]([O:21][c:22]2[cH:23][c:24]3[cH:25][c:26]([C:31](=[O:32])[N:33]4[CH2:34][CH2:35][C:36]([F:39])([F:40])[CH2:37][CH2:38]4)[nH:27][c:28]3[cH:29][cH:30]2)[CH2:19][CH2:20]1)([CH3:12])([CH3:13])[CH3:14].[Cl:41][CH2:42][Cl:43].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH:15]1[CH2:16][CH2:17][CH:18]([O:21][c:22]2[cH:23][c:24]3[cH:25][c:26]([C:31](=[O:32])[N:33]4[CH2:34][CH2:35][C:36]([F:39])([F:40])[CH2:37][CH2:38]4)[nH:27][c:28]3[cH:29][cH:30]2)[CH2:19][CH2:20]1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 670179124-[2-(4,4-Difluoro-piperidine-1-carbonyl)-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 67017913(4,4-Difluoro-piperidin-1-yl)-[5-(piperidin-4-yloxy)-1H-indol-2-yl]-methanone

출처 및 근거

ORD 기록
ord-1a163849320b4ff9b6979d7bea3f6e73
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

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