Cyclopentyl 4-nitrophenyl carbonate → 1-[(Cyclopentyloxy)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate

HRID 1550581Notes

Reaction equation

HRID 1550581 reaction equation
[C:1]([O:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1)([O:8][c:9]1[cH:10][cH:11][c:12]([N+:13]([O-:14])=[O:15])[cH:16][cH:17]1)=[O:18].[NH2:19][c:20]1[n:21][c:22]([N:45]2[CH2:46][CH2:47][N:48]([CH3:51])[CH2:49][CH2:50]2)[cH:23][c:24](-[c:26]2[cH:27][cH:28][c:29]3[c:34]([cH:35]2)[CH2:33][N:32]([C:36](=[O:37])[O:38][CH:39]2[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]2)[CH2:31][CH2:30]3)[n:25]1>>[C:1]([O:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1)(=[O:18])[N:42]1[CH2:41][CH2:40][CH:39]([O:38][C:36]([N:32]2[CH2:31][CH2:30][c:29]3[cH:28][cH:27][c:26](-[c:24]4[cH:23][c:22]([N:45]5[CH2:46][CH2:47][N:48]([CH3:51])[CH2:49][CH2:50]5)[n:21][c:20]([NH2:19])[n:25]4)[cH:35][c:34]3[CH2:33]2)=[O:37])[CH2:44][CH2:43]1

Participants

3

Reactant 2

HCID 54340011Cyclopentyl 4-nitrophenyl carbonateHCID 59496558piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate

Product 1

HCID 497795891-[(Cyclopentyloxy)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate

Sources & evidence

ORD record
ord-e206b1af0252488da092ae776412d66a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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