Acetic Acid → 5,7-Dichlorospiro[isoindoline-1,4'-piperidin]-3-one

HRID 1551131Notes

Reaction equation

HRID 1551131 reaction equation
[CH3:18][C:19](=[O:20])[OH:21].[Cl:1][c:2]1[cH:3][c:4]2[c:8]([c:9]([Cl:11])[cH:10]1)[C:7]1([NH:6][C:5]2=[O:17])[CH2:12][CH2:13][NH:14][CH:15]=[CH:16]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([c:9]([Cl:11])[cH:10]1)[C:7]1([NH:6][C:5]2=[O:17])[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 582957155,7-dichloro-2',3'-dihydro-1'H-spiro[isoindoline-1,4'-pyridin]-3-one

Product 1

HCID 582957645,7-Dichlorospiro[isoindoline-1,4'-piperidin]-3-one

Sources & evidence

ORD record
ord-83aa850f9c4e455195030c0cc64ad045
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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