2-(4-(4-(chloromethyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)-5-ethylpyrimidine → 5-Ethyl-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)pyrimidine

HRID 1551381Notes

Reaction equation

HRID 1551381 reaction equation
[Cl:1][CH2:2][c:3]1[cH:4][n:5][n:6]([CH:12]2[CH2:13][CH2:14][N:15]([c:18]3[n:19][cH:20][c:21]([CH2:24][CH3:25])[cH:22][n:23]3)[CH2:16][CH2:17]2)[c:7]1[C:8]([F:9])([F:10])[F:11].[F:26][c:27]1[c:28]([OH:38])[cH:29][cH:30][c:31](-[n:33]2[n:34][n:35][n:36][cH:37]2)[cH:32]1>>[CH2:2]([c:3]1[cH:4][n:5][n:6]([CH:12]2[CH2:13][CH2:14][N:15]([c:18]3[n:19][cH:20][c:21]([CH2:24][CH3:25])[cH:22][n:23]3)[CH2:16][CH2:17]2)[c:7]1[C:8]([F:9])([F:10])[F:11])[O:38][c:28]1[c:27]([F:26])[cH:32][c:31](-[n:33]2[n:34][n:35][n:36][cH:37]2)[cH:30][cH:29]1

Participants

3

Reactant 2

HCID 577083712-(4-(4-(chloromethyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)-5-ethylpyrimidineHCID 581143232-fluoro-4-(1H-1,2,3,4-tetrazol-1-yl)phenol

Product 1

HCID 251750865-Ethyl-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)pyrimidine

Sources & evidence

ORD record
ord-a1a10ff44648496d8b12fe5249954a27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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