4-(4-Fluorophenyl)cyclohexan-1-one → Trans 1-[4-(4-fluorophenyl)-1-cyclohexyl]-4-[(2,5-difluorophenyl)methyl]piperidine
Reaction equation
[F:15][c:16]1[c:17]([CH2:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[cH:25][c:26]([F:29])[cH:27][cH:28]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][CH:11]([N:22]3[CH2:21][CH2:20][CH:19]([CH2:18][c:17]4[c:16]([F:15])[cH:28][cH:27][c:26]([F:29])[cH:25]4)[CH2:24][CH2:23]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-886dc929aa1b4247a553a42c244cac2e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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