7-(chloromethyl)-3-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one → 7-({6-[2-(5-Chloro-2,4-dimethoxyphenyl)ethyl]-6-cyclopentyl-4-hydroxy-2-oxo-5,6-dihydro-2H-pyran-3-yl}methyl)-3-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

HRID 1551727Notes

Reaction equation

HRID 1551727 reaction equation
[Cl:14][CH2:15][c:16]1[n:17]([CH3:18])[n:19][c:20]([CH3:21])[n:22]1.[Cl:1][CH2:2][c:3]1[n:4][c:5]2[n:6]([c:7](=[O:9])[cH:8]1)[c:10]([CH3:13])[cH:11][s:12]2.[Cl:23][c:24]1[c:25]([O:47][CH3:48])[cH:26][c:27]([O:45][CH3:46])[c:28]([CH2:30][CH2:31][C:32]2([CH:40]3[CH2:41][CH2:42][CH2:43][CH2:44]3)[CH2:33][C:34](=[O:39])[CH2:35][C:36](=[O:38])[O:37]2)[cH:29]1>>[CH2:2]([c:3]1[n:4][c:5]2[n:6]([c:7](=[O:9])[cH:8]1)[c:10]([CH3:13])[cH:11][s:12]2)[C:35]1=[C:34]([OH:39])[CH2:33][C:32]([CH2:31][CH2:30][c:28]2[c:27]([O:45][CH3:46])[cH:26][c:25]([O:47][CH3:48])[c:24]([Cl:23])[cH:29]2)([CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44]2)[O:37][C:36]1=[O:38]

Participants

4

Reactant 3

HCID 43541347-(chloromethyl)-3-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-oneHCID 131031005-(chloromethyl)-1,3-dimethyl-1H-1,2,4-triazoleHCID 167287016-[2-(5-Chloro-2,4-dimethoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dione

Product 1

HCID 587623847-({6-[2-(5-Chloro-2,4-dimethoxyphenyl)ethyl]-6-cyclopentyl-4-hydroxy-2-oxo-5,6-dihydro-2H-pyran-3-yl}methyl)-3-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

Sources & evidence

ORD record
ord-4277c3f373d845bdbc4ed6fcc8cc9926
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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