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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1552274Generated: October 30, 2026

Dimethylformamide → N-(4-(6-(4-(Benzyloxy)phenylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide

https://huagongshe.com/reaction/1552274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantDiisopropyl EtherHCID 7914—
ReactantTetrafluoroborateHCID 26255—
ReactantDiisopropylethylamineHCID 81531—
ReactantO-benzotriazol-1-yl-tetramethyluroniumHCID 130500—
Reactant1-(4-(6-Aminopyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)thioureaHCID 11538912—
ReactantN1-(4-(2-(4-Methoxybenzylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamideHCID 59852883—
Reactant6-(4-Amino-2-fluorophenoxy)-N-(4-(benzyloxy)phenyl)pyrimidin-4-amineHCID 59853003—
ProductN-(4-(6-(4-(Benzyloxy)phenylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamideHCID 59853038—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (1/10)
ORD IDord-eaca7fbd1e67468fa083ab40d605d712
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (1/10)