Sodium ion → (RS)-1-(5-methoxy-2,3-dihydro-1H-indol-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

HRID 1552636Notes

Reaction equation

HRID 1552636 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:9]([cH:10][cH:11]1)[N:8]([S:12]([c:13]1[cH:14][cH:15][c:16]([CH3:17])[cH:18][cH:19]1)(=[O:20])=[O:21])[CH:7]([CH2:22][N:23]1[CH2:24][CH2:25][C:26]([OH:29])([CH2:30][c:31]3[cH:32][cH:33][c:34]([CH3:37])[cH:35][cH:36]3)[CH2:27][CH2:28]1)[CH2:6]2.[CH3:39][O:40][CH2:41][CH2:42][O:43][Al+:44][O:45][CH2:46][CH2:47][O:48][CH3:49].[CH3:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1.[H-:38].[H-:51].[Na+:50].[Na+:53].[OH-:52]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:9]([cH:10][cH:11]1)[NH:8][CH:7]([CH2:22][N:23]1[CH2:24][CH2:25][C:26]([OH:29])([CH2:30][c:31]3[cH:32][cH:33][c:34]([CH3:37])[cH:35][cH:36]3)[CH2:27][CH2:28]1)[CH2:6]2

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 961HydroxideHCID 1140TolueneHCID 166653Hydride2×HCID 18764105Bis(2-methoxyethoxy)alumanyliumHCID 22628326HCID 22628326, compound

Product 1

HCID 22628339(RS)-1-(5-methoxy-2,3-dihydro-1H-indol-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-20d0da8d18ee4c3ea8ce79f17b562336
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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