4-((3-Methoxyphenyl)amino)-8-methyl-6-((3-(4-oxopiperidine-1-carbonyl)phenyl)sulfonyl)quinoline-3-carboxamide → 6-[3-[4-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]piperidine-1-carbonyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH:7]([CH2:8][NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([c:20]1[cH:21][c:22]([S:23]([c:24]2[cH:25][c:26]3[c:27]([c:28]([CH3:29])[cH:30]2)[n:31][cH:32][c:33]([C:34]([NH2:35])=[O:36])[c:37]3[NH:38][c:39]2[cH:40][cH:41][cH:42][c:43]([O:44][CH3:45])[cH:46]2)(=[O:47])=[O:48])[cH:49][cH:50][cH:51]1)=[O:52])[c:53]1[c:54]2[cH:55][cH:56][c:57](=[O:64])[nH:58][c:59]2[c:60]([OH:63])[cH:61][cH:62]1)([CH3:65])[CH3:66].[CH3:67][O:68][c:69]1[cH:70][c:71]([NH:75][c:76]2[c:77]([C:105](=[O:106])[NH2:107])[cH:78][n:79][c:80]3[c:81]([CH3:104])[cH:82][c:83]([S:86](=[O:87])(=[O:88])[c:89]4[cH:90][c:91]([C:95](=[O:96])[N:97]5[CH2:98][CH2:99][C:100](=[O:103])[CH2:101][CH2:102]5)[cH:92][cH:93][cH:94]4)[cH:84][c:85]23)[cH:72][cH:73][cH:74]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH:7]([CH2:8][NH:9][CH:100]1[CH2:99][CH2:98][N:97]([C:95]([c:91]2[cH:90][c:89]([S:86]([c:83]3[cH:82][c:81]([CH3:104])[c:80]4[n:79][cH:78][c:77]([C:105](=[O:106])[NH2:107])[c:76]([NH:75][c:71]5[cH:70][c:69]([O:68][CH3:67])[cH:74][cH:73][cH:72]5)[c:85]4[cH:84]3)(=[O:87])=[O:88])[cH:94][cH:93][cH:92]2)=[O:96])[CH2:102][CH2:101]1)[c:53]1[c:54]2[cH:55][cH:56][c:57](=[O:64])[nH:58][c:59]2[c:60]([OH:63])[cH:61][cH:62]1)([CH3:65])[CH3:66]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-68d2656341e944bc9a3127c5f047cd48
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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