HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15533Generated: October 28, 2026
Sodium Hydroxide → HCID 58644774, compound
https://huagongshe.com/reaction/15533
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester | HCID 67199280 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58644774 | HCID 58644774 | — |
Reaction Steps
The product of step d.) was dissolved in 3 mL ethanol, treated with 1 M NaOH (500 μL), and heated to 70° C. for one hour. The reaction was diluted in DCM and extracted with water. The aqueous layer was acidified with 1 M HCl and extracted with DCM. The organic layer was washed with water, concentrated and purified by preparative LCMS to give the title compound. MS: ESI (positive): 334 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07732618B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-c0267d7a4d17472887b6e0ded77623d3 |
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| Source note | uspto-grants-2010_06 |
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