Dichloromethane → 4-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, methyl ester

HRID 1554105Notes

Reaction equation

HRID 1554105 reaction equation
[CH3:29][O:30][c:31]1[cH:32][c:33]([N:37]2[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]2)[cH:34][cH:35][cH:36]1.[Cl:43][CH2:44][Cl:45].[F:1][c:2]1[c:3]([N:14]=[C:15]=[N:16][c:17]2[c:18]([O:27][CH3:28])[cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[c:4]([CH:8]=[CH:9][C:10](=[O:11])[O:12][CH3:13])[cH:5][cH:6][cH:7]1>>[F:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[CH:8]([CH2:9][C:10](=[O:11])[O:12][CH3:13])[N:16]([c:17]1[c:18]([O:27][CH3:28])[cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]1)[C:15]([N:40]1[CH2:39][CH2:38][N:37]([c:33]3[cH:32][c:31]([O:30][CH3:29])[cH:36][cH:35][cH:34]3)[CH2:42][CH2:41]1)=[N:14]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 81430N-(3-methoxyphenyl)piperazineHCID 72436574Methyl 3-[3-fluoro-2-[[2-methoxy-5-(trifluoromethyl)phenyl]iminomethylideneamino]phenyl]prop-2-enoate

Product 1

HCID 119836914-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, methyl ester

Sources & evidence

ORD record
ord-57665c8e63c647da887abe639905c564
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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