Ethanol → tert-butyl N-[[4-[4-[5-(acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl]phenyl]methyl]-N-(3-fluoropropyl)carbamate

HRID 1554392Notes

Reaction equation

HRID 1554392 reaction equation
[C:28]([CH3:29])([CH3:30])([CH3:31])[O:32][C:33]([N:34]([CH2:35][CH2:36][CH2:37][F:38])[CH2:39][c:40]1[cH:41][cH:42][c:43]([Br:46])[cH:44][cH:45]1)=[O:47].[C:51](=[O:52])([O-:53])[O-:54].[CH2:57]1[O:58][CH2:59][CH2:60][O:61][CH2:62]1.[CH3:48][CH2:49][OH:50].[F:1][c:2]1[cH:3][c:4]([N:17]2[C:18](=[O:27])[O:19][CH:20]([CH2:22][NH:23][C:24]([CH3:25])=[O:26])[CH2:21]2)[cH:5][cH:6][c:7]1[B:8]1[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]1.[K+:55].[K+:56].[OH2:63]>>[F:1][c:2]1[cH:3][c:4]([N:17]2[C:18](=[O:27])[O:19][CH:20]([CH2:22][NH:23][C:24]([CH3:25])=[O:26])[CH2:21]2)[cH:5][cH:6][c:7]1-[c:43]1[cH:42][cH:41][c:40]([CH2:39][N:34]([C:33]([O:32][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:47])[CH2:35][CH2:36][CH2:37][F:38])[cH:45][cH:44]1

Participants

8

Reactant 7

HCID 702EthanolHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 22273985N-{3-[3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamideHCID 58721921(4-Bromo-benzyl)-(3-fluoro-propyl)-carbamic acid tert-butyl ester

Product 1

HCID 68540790tert-butyl N-[[4-[4-[5-(acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl]phenyl]methyl]-N-(3-fluoropropyl)carbamate

Sources & evidence

ORD record
ord-8d261c140ad04db5a0aa7b7ffa0329a6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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