(1-methyl-1H-pyrazol-4-yl)methanamine → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide

HRID 1554589Notes

Reaction equation

HRID 1554589 reaction equation
[CH3:50][n:51]1[n:52][cH:53][c:54]([CH2:56][NH2:57])[cH:55]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[s:6][cH:7][c:8]([CH2:9][N:10]3[CH2:11][CH2:12][N:13]([c:14]4[s:15][c:16]([C:17]([OH:18])=[O:19])[c:20]([CH3:21])[n:22]4)[C:23]3=[O:24])[c:25]2[cH:26]1.[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:47])[N:35]([c:38]3[s:39][c:40]([C:44](=[O:45])[OH:46])[c:41]([CH3:43])[n:42]3)[CH2:36][CH2:37]2)[cH:48][cH:49]1>>[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:47])[N:35]([c:38]3[s:39][c:40]([C:44](=[O:45])[NH:57][CH2:56][c:54]4[cH:53][n:52][n:51]([CH3:50])[cH:55]4)[c:41]([CH3:43])[n:42]3)[CH2:36][CH2:37]2)[cH:48][cH:49]1

Participants

4

Reactant 3

HCID 671225(1-methyl-1H-pyrazol-4-yl)methanamineHCID 579197992-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acidHCID 580315052-(3-((5-Chlorobenzo[b]thiophen-3-yl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Product 1

HCID 594811972-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide

Sources & evidence

ORD record
ord-c239985dc5444e049703315ec24e79db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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