5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid → N-{3-Cyano-4-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-5-methyl-1-(4-trifluoromethylphenyl)pyrazole 4-carboxamide

HRID 1554687Notes

Reaction equation

HRID 1554687 reaction equation
[CH3:1][c:2]1[c:3]([C:17](=[O:18])[OH:19])[cH:4][n:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]1.[NH2:20][c:21]1[cH:22][cH:23][c:24]([N:29]2[CH2:30][CH2:31][N:32]([CH:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)[CH2:33][CH2:34]2)[c:25]([C:26]#[N:27])[cH:28]1>>[CH3:1][c:2]1[c:3]([C:17](=[O:18])[NH:20][c:21]2[cH:22][cH:23][c:24]([N:29]3[CH2:30][CH2:31][N:32]([CH:35]4[CH2:36][CH2:37][O:38][CH2:39][CH2:40]4)[CH2:33][CH2:34]3)[c:25]([C:26]#[N:27])[cH:28]2)[cH:4][n:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]1

Participants

3

Reactant 2

HCID 107784295-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acidHCID 219423235-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile

Product 1

HCID 22228000N-{3-Cyano-4-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-5-methyl-1-(4-trifluoromethylphenyl)pyrazole 4-carboxamide

Sources & evidence

ORD record
ord-a880214c4fb74a87a9ada929f77d0c37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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