2-(Bromomethyl)tetrahydro-2H-pyran → 4'-chloro-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

HRID 1555285Notes

Reaction equation

HRID 1555285 reaction equation
[Br:44][CH2:45][c:46]1[o:47][c:48]([C:51]([F:52])([F:53])[F:54])[cH:49][cH:50]1.[Br:55][CH2:56][CH:57]1[CH2:58][CH2:59][CH2:60][CH2:61][O:62]1.[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1.[NH:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[C:30]2([CH2:31][O:32][c:33]3[cH:34][c:35]4[c:36]([cH:37][c:38]32)[CH2:39][CH2:40][O:41]4)[C:42]1=[O:43]>>[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH2:45][c:46]1[o:47][c:48]([C:51]([F:52])([F:53])[F:54])[cH:49][cH:50]1)[C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1

Participants

5

Reactant 4

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-oneHCID 59352596HCID 59352596, compound

Product 1

HCID 593523654'-chloro-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-207c10e02fd643c7910494a7fc1dc22d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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