Water → tert. Butyl (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-pyrrolidine-1-carboxylate

HRID 1555379Notes

Reaction equation

HRID 1555379 reaction equation
[B-:10]([F:11])([F:12])([F:13])[F:14].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1.[Cl:47][CH2:48][Cl:49].[NH2:32][CH:33]1[CH2:34][N:35]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:36][CH:37]1[OH:38].[OH2:46].[n:15]1([O:16][C:17]([N:18]([CH3:19])[CH3:20])=[N+:21]([CH3:22])[CH3:23])[c:24]2[cH:25][cH:26][cH:27][cH:28][c:29]2[n:30][n:31]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:9])[NH:32][CH:33]2[CH2:34][N:35]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:36][CH:37]2[OH:38])[s:6]1

Participants

7

Reactant 6

HCID 962WaterHCID 6344DichloromethaneHCID 26255TetrafluoroborateHCID 950485-Chloro-2-thiophenecarboxylic acidHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 11229445tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 74835283tert. Butyl (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-67422ef2e0584c7f9e67ed50c047926f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…