Dichloromethane → 3-(4-{[4-[5-Fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenol

HRID 1556313Notes

Reaction equation

HRID 1556313 reaction equation
[B:40]([Br:41])([Br:42])[Br:43].[Cl:44][CH2:45][Cl:46].[F:1][C:2]([C:3]([CH2:4][C:5]([CH3:6])([CH3:7])[c:8]1[c:9]([O:15][CH3:16])[cH:10][cH:11][c:12]([F:14])[cH:13]1)([OH:17])[CH2:18][NH:19][c:20]1[c:21]2[cH:22][n:23][n:24](-[c:30]3[cH:31][c:32]([O:36][CH3:37])[cH:33][cH:34][cH:35]3)[c:25]2[cH:26][c:27]([CH3:29])[cH:28]1)([F:38])[F:39]>>[F:1][C:2]([C:3]([CH2:4][C:5]([CH3:6])([CH3:7])[c:8]1[c:9]([O:15][CH3:16])[cH:10][cH:11][c:12]([F:14])[cH:13]1)([OH:17])[CH2:18][NH:19][c:20]1[c:21]2[cH:22][n:23][n:24](-[c:30]3[cH:31][c:32]([OH:36])[cH:33][cH:34][cH:35]3)[c:25]2[cH:26][c:27]([CH3:29])[cH:28]1)([F:38])[F:39]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 576159421,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-[({6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl}amino)methyl]-2-pentanol

Product 1

HCID 576159303-(4-{[4-[5-Fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenol

Sources & evidence

ORD record
ord-964bba9a84284f11b92dd8ff83d3c2eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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